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Protective Role of Menthone against Indomethacin-induced Gastric Ulcers in Rat Model. 3 https://doi.org/10.58209/gmjm.3.4.121
URL: http://daneshafarand.org/article-1-236-en.html
URL: http://daneshafarand.org/article-1-236-en.html
Abstract: (1559 Views)
Aims: The use of novel agents has been considered for the management of different diseases. Gastric ulcers are a common disease. This study aimed to evaluate the effects of menthone, a novel agent, on gastric ulcers in an Indomethacin-induced model rat.
Materials & Methods: Animals were divided into 3 groups: 1) a Control group that received only distilled water, 2) Animals were treated with 40mg/kg bw omeprazole (Omeprazole), and 3) Animals were treated with 40mg/kg bw menthone (Menthone). A dose of indomethacin (30mg/kg body weight) was administered per animal. Gastric secretions and antioxidant parameters were evaluated at the end of the trial.
Findings: It was observed that an increased ulcer index, gastric volume, malondialdehyde level, and decreased superoxide dismutase and pepsin activity in the control group in comparison to other groups (p<0.05). The use of menthone and Omeprazole could alleviate the effects of indomethacin.
Conclusion: Menthone may not have positive effects similar to Omeprazole, but it could attenuate the effects of indomethacin.
Materials & Methods: Animals were divided into 3 groups: 1) a Control group that received only distilled water, 2) Animals were treated with 40mg/kg bw omeprazole (Omeprazole), and 3) Animals were treated with 40mg/kg bw menthone (Menthone). A dose of indomethacin (30mg/kg body weight) was administered per animal. Gastric secretions and antioxidant parameters were evaluated at the end of the trial.
Findings: It was observed that an increased ulcer index, gastric volume, malondialdehyde level, and decreased superoxide dismutase and pepsin activity in the control group in comparison to other groups (p<0.05). The use of menthone and Omeprazole could alleviate the effects of indomethacin.
Conclusion: Menthone may not have positive effects similar to Omeprazole, but it could attenuate the effects of indomethacin.
Article Type: Original Research |
Subject:
Biotechnology
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