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Protective Effects of Black Cumin Nanophytosome in Rats Exposed to Chronic Stress. 3 https://doi.org/10.58209/gmjm.4.2.77
URL: http://daneshafarand.org/article-1-263-en.html
URL: http://daneshafarand.org/article-1-263-en.html
Abstract: (1697 Views)
Aims: Stress occurs during life and causes psychological problems that must be treated. Consumption of plants and their derivations may decrease the negative effects of stress. This study aimed to evaluate the effects of black cumin nanophytosomes on behavioral responses, stress oxidative biomarkers, and brain-derived neurotrophic factor changes in rats exposed to chronic stress.
Materials & Methods: The rats were divided into six groups of non-stressed (negative control or NC) and stressed treated with 0mg/kg of cumin essential oil (stress) and 20mg/kg of cumin (20-C), 40mg/kg of cumin (40-C), 20mg/kg of cumin nanophytosome (20-CN) and 40mg/kg of cumin nanophytosome (40-CN). Anxiety and depression-like behaviors, brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, malondialdehyde concentrations, superoxide dismutase, and glutathione peroxidase activities were assessed.
Findings: Stress increased anxiety and depression-like behaviors and malondialdehyde concentration while decreasing brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with NC rats. Cumin decreased anxiety and depression-like behaviors and malondialdehyde concentration while increased brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with rats in the stress group.
Conclusion: Cumin, especially in the highest concentrations and nanophytosome coatings, can manage stress and decrease psychological behaviors by increasing brain-derived neurotrophic factors and the activities of antioxidant enzymes.
Materials & Methods: The rats were divided into six groups of non-stressed (negative control or NC) and stressed treated with 0mg/kg of cumin essential oil (stress) and 20mg/kg of cumin (20-C), 40mg/kg of cumin (40-C), 20mg/kg of cumin nanophytosome (20-CN) and 40mg/kg of cumin nanophytosome (40-CN). Anxiety and depression-like behaviors, brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, malondialdehyde concentrations, superoxide dismutase, and glutathione peroxidase activities were assessed.
Findings: Stress increased anxiety and depression-like behaviors and malondialdehyde concentration while decreasing brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with NC rats. Cumin decreased anxiety and depression-like behaviors and malondialdehyde concentration while increased brain-derived neurotrophic factor levels, ferric-reducing antioxidant power, superoxide dismutase, and glutathione peroxidase concentrations compared with rats in the stress group.
Conclusion: Cumin, especially in the highest concentrations and nanophytosome coatings, can manage stress and decrease psychological behaviors by increasing brain-derived neurotrophic factors and the activities of antioxidant enzymes.
Article Type: Original Research |
Subject:
Pharmacy
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