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Volume 13, Issue 4 (2025)
Health Educ Health Promot 2025, 13(4): 617-623 |
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Received: 2025/09/10 | Accepted: 2025/10/29 | Published: 2025/11/10
Received: 2025/09/10 | Accepted: 2025/10/29 | Published: 2025/11/10
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Alifariki L, Salma W, Sudayasa I. Effective Determinant Factors on the Quality of Life in Hypertensive Wakatobi Patients, Indonesia. Health Educ Health Promot 2025; 13 (4) :617-623
URL: http://hehp.daneshafarand.org/article-4-82920-en.html
URL: http://hehp.daneshafarand.org/article-4-82920-en.html
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1- Department of Nursing, Faculty of Medicine, Halu Oleo University, Kendari, Indonesia
2- Department of Community Medicine, Faculty of Medicine, Halu Oleo University, Kendari, Indonesia
2- Department of Community Medicine, Faculty of Medicine, Halu Oleo University, Kendari, Indonesia
Abstract (708 Views)
Aims: This study aimed to analyze the role of medication adherence as a mediator in the relationship between determinant factors and quality of life among hypertensive patients in the coastal communities of Wakatobi District.
Instrument & Methods: This cross-sectional design with a quantitative approach was conducted on200 hypertensive patients living in the coastal areas of Wakatobi District selected using multistage cluster sampling. Data were collected through structured interviews using the WHO Quality of Life Assessment Instrument for quality of life, the Morisky Medication Adherence Scale for medication adherence, and questionnaires on social support, illness perception, knowledge, attitude, and motivation. Data analysis was done using Chi-square tests, and multivariate analysis using structural equation modeling-partial least squares with SmartPLS.
Findings: Social support, illness perception, knowledge, attitude, and motivation were significantly associated with medication adherence (p<0.05). Medication adherence was also significantly associated with quality of life (p=0.013). SEM-PLS confirmed that adherence served as a mediator in the relationship between determinant factors and quality of life.
Conclusion: Medication adherence plays a crucial mediating role in the relationship between determinant Factors and the quality of life of hypertensive patients in the coastal communities of Wakatobi District.
Instrument & Methods: This cross-sectional design with a quantitative approach was conducted on200 hypertensive patients living in the coastal areas of Wakatobi District selected using multistage cluster sampling. Data were collected through structured interviews using the WHO Quality of Life Assessment Instrument for quality of life, the Morisky Medication Adherence Scale for medication adherence, and questionnaires on social support, illness perception, knowledge, attitude, and motivation. Data analysis was done using Chi-square tests, and multivariate analysis using structural equation modeling-partial least squares with SmartPLS.
Findings: Social support, illness perception, knowledge, attitude, and motivation were significantly associated with medication adherence (p<0.05). Medication adherence was also significantly associated with quality of life (p=0.013). SEM-PLS confirmed that adherence served as a mediator in the relationship between determinant factors and quality of life.
Conclusion: Medication adherence plays a crucial mediating role in the relationship between determinant Factors and the quality of life of hypertensive patients in the coastal communities of Wakatobi District.
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References
1. Alifariki LO, Tukatman T, Bangu B, Siagian H. Differences of sodium consumption pattern hypertension sufferer in coastal and highland communities in Wakatobi islands. REVISTA BIONATURA. 2021;6(2):1736-40. [Link] [DOI:10.21931/RB/2021.01.02.12]
2. Sudayasa IP, Husdaningsih F, Alifariki LO. Polymorphism of gene ACE I/D and family history of hypertension as predisposition of hypertension. Malays J Med Health Sci. 2023;19(3):263-41. [Link] [DOI:10.47836/mjmhs.19.3.22]
3. WHO. Hypertension [Internet]. Geneva: World Health Organization; 2023 [cited 2025 April 24]. Available from: https://www.who.int/news-room/fact-sheets/detail/hypertension. [Link]
4. Zygmuntowicz M, Owczarek A, Elibol A, Olszanecka-Glinianowicz M, Chudek J. Blood pressure for optimal health-related quality of life in hypertensive patients. J Hypertens. 2013;31(4):830-9. [Link] [DOI:10.1097/HJH.0b013e32835ebdd7]
5. Zheng E, Xu J, Xu J, Zeng X, Tan WJ, Li J, et al. Health-related quality of life and its influencing factors for elderly patients with hypertension: Evidence from Heilongjiang Province, China. Front Public Health. 2021;9:654822. [Link] [DOI:10.3389/fpubh.2021.654822]
6. Kemenkes. The 2023 National Basic Health Research Report (Riskesdas) [Internet]. Jakarta: Kemenkes; 2023 [cited 2025 March 11]. Available from: https://www.badankebijakan.kemkes.go.id/laporan-hasil-survei/. [Indonesian] [Link]
7. Ross S, Walker A, MacLeod MJ. Patient compliance in hypertension: Role of illness perceptions and treatment beliefs. J Hum Hypertens. 2004;18(9):607-13. [Link] [DOI:10.1038/sj.jhh.1001721]
8. Noreen N, Bashir F, Khan AW, Safi MM, Lashari WA, Hering D. Determinants of adherence to antihypertension medications among patients at a tertiary care hospital in Islamabad, Pakistan, 2019. Prev Chronic Dis. 2023;20:E42. [Link] [DOI:10.5888/pcd20.220231]
9. Alsaqabi YS, Rabbani U. Medication adherence and its association with quality of life among hypertensive patients attending primary health care centers in Saudi Arabia. Cureus. 2020;12(12):e11853. [Link] [DOI:10.7759/cureus.11853]
10. Molintao WP, Ariska A, Ambitan RO. The relationship between family support and medication adherence among patients with hypertension at Towuntu Timur Primary Health Care, Southeast Minahasa Regency. J Community Emerg. 2019;7(2):156-69. [Indonesian] [Link]
11. Ye R, Liu K, Zhang Z, Gong S, Chen X. Health-related quality of life of hypertension in China: A systematic review and meta-analysis. J Cardiovasc Med. 2018;19(8):430-8. [Link] [DOI:10.2459/JCM.0000000000000678]
12. Yulianita H, Hariyati RTS, Pujasari H, Komariah M, Fitria N. Improving the quality of nursing documentation using supervision of the head of room. Eurasian J Biosci. 2020;14(2):7579-84. [Link]
13. Youssef RM, Moubarak II, Kamel MI. Factors affecting the quality of life of hypertensive patients. East Mediterr Health J. 2005;11(1-2):109-18. [Link]
14. Purwanta P, Sadewa DMA, Sahrinanda D, Rizky I, Muthoharoh IM, Yunistyaningrum V. Enabling the grass root: Health cadres empowerment program in efforts to prevent and manage hypertension in the Tanjung sub-village community. Indones J Community Engagem. 2023;9(3):181-7. [Link] [DOI:10.22146/jpkm.86250]
15. Syahroni, Wibisana E, Deswita R. The relationship between self-efficacy and adherence to a low-sodium diet among elderly patients with hypertension in the coastal area of Pakuhaji Primary Health Care. J Pubnursing Sci. 2024;2(2):51-7. [Indonesian] [Link] [DOI:10.69606/jps.v2i02.114]
16. Safitri EM, Irianto SE, Rahayu D, Setiaji B. Factors influencing treatment adherence among patients with hypertension in Pesisir Barat Regency in 2023. J-CEKI. 2024;3(5):4358-77. [Indonesian] [Link]
17. Skevington SM, Lotfy M, O'Connell KA. The World Health Organization's WHOQOL-BREF quality of life assessment: psychometric properties and results of the international field trial. A report from the WHOQOL group. Qual life Res. 2004;13(2):299-310. [Link] [DOI:10.1023/B:QURE.0000018486.91360.00]
18. Morisky DE, Ang A, Krousel‐Wood M, Ward HJ. Retracted: predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens. 2008;10(5):348-54. [Link] [DOI:10.1111/j.1751-7176.2008.07572.x]
19. Zimet GD, Dahlem NW, Zimet SG, Farley GK. The multidimensional scale of perceived social support. J Person Assess. 1988;52(1):30-41. [Link] [DOI:10.1207/s15327752jpa5201_2]
20. Oliveria SA, Chen RS, McCarthy BD, Davis CC, Hill MN. Hypertension knowledge, awareness, and attitudes in a hypertensive population. Journal of general internal medicine. 2005;20(3):219-25. [Link] [DOI:10.1111/j.1525-1497.2005.30353.x]
21. Religioni U, Barrios-Rodríguez R, Requena P, Borowska M, Ostrowski J. Enhancing therapy adherence: Impact on clinical outcomes, healthcare costs, and patient quality of life. Medicina. 2025;61(1):153. [Link] [DOI:10.3390/medicina61010153]
22. Kvarnström K, Westerholm A, Airaksinen M, Liira H. Factors contributing to medication adherence in patients with a chronic condition: A scoping review of qualitative research. Pharmaceutics. 2021;13(7):1100. [Link] [DOI:10.3390/pharmaceutics13071100]
23. Ghembaza MA, Senoussaoui Y, Kendouci Tani M, Meguenni K. Impact of patient knowledge of hypertension complications on adherence to antihypertensive therapy. Curr Hypertens Rev. 2014;10(1):41-8. [Link] [DOI:10.2174/157340211001141111160653]
24. Sudharsanan N, Ali MK, McConnell M. Hypertension knowledge and treatment initiation, adherence, and discontinuation among adults in Chennai, India: A cross-sectional study. BMJ Open. 2021;11(1):e040252. [Link] [DOI:10.1136/bmjopen-2020-040252]
25. Ha NT, Duy HT, Le NH, Khanal V, Moorin R. Quality of life among people living with hypertension in a rural Vietnam community. BMC Public Health. 2014;14(1):833. [Link] [DOI:10.1186/1471-2458-14-833]
26. Joffres M, Falaschetti E, Gillespie C, Robitaille C, Loustalot F, Poulter N, et al. Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: A cross-sectional study. BMJ Open. 2013;3(8):e003423. [Link] [DOI:10.1136/bmjopen-2013-003423]
27. Morisky DE, Ang A, Krousel‐Wood M, Ward HJ. Retracted: Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens. 2008;10(5):348-54. [Link] [DOI:10.1111/j.1751-7176.2008.07572.x]
28. Wulandari N, Maifitrianti M, Hasanah F, Atika S, Putri RD. Medication adherence assessment among patients with type 2 diabetes mellitus treated polytherapy in Indonesian community health center: A cross sectional-study. J Pharm Bioallied Sci. 2020;12(Suppl 2):S758-62. [Link] [DOI:10.4103/jpbs.JPBS_257_19]
29. Alhalaiqa F, Deane KHO, Nawafleh AH, Clark A, Gray R. Adherence therapy for medication non-compliant patients with hypertension: A randomised controlled trial. J Hum Hypertens. 2012;26(2):117-26. [Link] [DOI:10.1038/jhh.2010.133]
30. Tahghighi H, Mortazavi H, Manteghi AA, Armat MR. The effect of comprehensive individual motivational-educational program on medication adherence in elderly patients with bipolar disorders: An experimental study. J Educ Health Promot. 2023;12(1):70. [Link] [DOI:10.4103/jehp.jehp_1109_22]
31. Uchmanowicz B, Jankowska EA, Uchmanowicz I, Morisky DE. Self-reported medication adherence measured with morisky medication adherence scales and its determinants in hypertensive patients aged ≥ 60 years: A systematic review and meta-analysis. Front Pharmacol. 2019;10:168. [Link] [DOI:10.3389/fphar.2019.00168]